Vol. 12, Issue 1 (2023)

Author(s):
Pal Rahul Keshavprasad, Ravikumar K, Senthilkumar K, Kathirvel S, Gopikrishnan D, Ganesan A, Selvaraju M and Ezakial Napolean R

Abstract:
Canine pyometra is a hormonally mediated acute or chronic poly-systemic diestrual disorder, characterized by accumulation of pus in the uterus of intact bitches, and is the most common genital disease resulting in high mortality rate if untreated. The present study involved a total of 7 bitches diagnosed for open cervix pyometra based on history, clinical signs, B-mode ultrasonography, haematological and biochemical changes on Day 0. The bitches were administered with methylergometrine maleate @ 0.125 mg/dog along with antibiotic and supportive fluid therapy; the doses were fixed based on body weight (For dogs weighing less than 15kg the dose was fixed as 0.125 mg/dog and for dogs with more than 15 kg body weight the dose was fixed as 0.25 mg/dog b.i.d P/O for 7 day) and Tab. Mifepristine @ 2.5 mg/ Kg B.Wt. for 7 days. Statistically significant changes (p<0.05) were observed in total leucocyte count between day 0 and day 7 of treatment. Haemoglobin, total erythrocyte count, neutrophils and lymphocytes of blood did not differ significantly. Ultrasonography on days 7 revealed significant reduction (p<0.05) in the diameter of the uterine horns compared to day 0. All the bitches recovered after 7 days with complete evacuation of pus. The study concluded that methylergometrine coupled with mifepristone along with supportive therapy can be utilized efficiently to treat open cervix pyometra in bitches without any side effects.