Vol. 11, Issue 5 (2022)

Author(s):
Joseph B Minari, Emmanuel O Oludipe, Musiliu O Ogunkanmi, Adedoyinsola Egbuwoku, Samuel O Adebudo and Jeremiah T Folaju

Abstract:
Bioactive component from medicinal plants continues to be the centre of research in treatment of ailments. In this study, we evaluated the inhibitory effect of ethanolic Garlic extract and its HPLC fatty acid elute on the histology and DNA of nickel chloride induced female albino rats (Rattus norvegicus). The result showed disparities in weight across groups throughout the experimental period, with the group treated with fatty acid having the highest weight. Tumour was observed in the negative control group. Result from PCR gene amplification (ULBP3, STX17, PRDX5, Il2 and CTLA4) showed distinct bands, which suggest the DNA was not damage. The histology showed variation in aggressiveness of nickel chloride pathogenesis in relation to treatment. This study help confirm the chemo-preventive properties of Garlic and suggest that, at least in part it fatty acid constitute fat deposition in tissues, could be detrimental to it ameliorative efficacy.