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- E-ISSN Number: 2277-7695
- P-ISSN Number: 2349-8242
- CODEN Code: PIHNBQ
- ZDB-Number: 2663038-2
- IC Journal ID: 7725
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Vol. 11, Issue 12 (2022)
Synthetic biology: Application in disease diagnosis
Author(s):
Vrushali Dhas and Shubhangi Warke
Vrushali Dhas and Shubhangi Warke
Abstract:
Synthetic biology is a logical extension of what has been called recombinant DNA (rDNA) technology or genetic engineering since 1970s. The subject combines various disciplines from within these domains, such as biotechnology, evolutionary biology, molecular biology, systems biology, biophysics, computer engineering, and genetic engineering. Synthetic biology aims to understand whole biological systems working as a unit, rather than investigating their individual components and design new genome. It has the potential to take the industry to new heights in coming years. Synthetic biology advances have been driven by dramatic cost reductions in DNA sequencing and DNA synthesis; by the development of sophisticated tools for genome editing, such as CRISPR/Cas9; and by advances in informatics, computational tools and infrastructure to facilitate and scale analysis and design.
Synthetic biology is a logical extension of what has been called recombinant DNA (rDNA) technology or genetic engineering since 1970s. The subject combines various disciplines from within these domains, such as biotechnology, evolutionary biology, molecular biology, systems biology, biophysics, computer engineering, and genetic engineering. Synthetic biology aims to understand whole biological systems working as a unit, rather than investigating their individual components and design new genome. It has the potential to take the industry to new heights in coming years. Synthetic biology advances have been driven by dramatic cost reductions in DNA sequencing and DNA synthesis; by the development of sophisticated tools for genome editing, such as CRISPR/Cas9; and by advances in informatics, computational tools and infrastructure to facilitate and scale analysis and design.
It is a relatively new field with the key aim of designing and constructing biological systems with novel functionalities. Today, synthetic biology devices are making their first steps in contributing new solutions to a number of biomedical challenges, such as emerging antimicrobial resistance and cancer therapy. Recent approaches and applications of synthetic biology include disease mechanism investigation and disease modeling, drug discovery and production, vaccine development and treatment of infectious diseases, cancer, and metabolic disorders. Similarly, progress is being made with ‘synthetic approaches’ in genetics and animal sciences, providing exciting opportunities to modulate, genome design and finally synthesis of animals for favorites traits.
Synthetic biology will potentially transform our response in combating future pandemics. Unleashing the full power of synthetic biology with appropriate regulations and checks will gear our society towards a healthier and safer future.
Pages: 119-123 | 335 Views 117 Downloads
How to cite this article:
Vrushali Dhas, Shubhangi Warke. Synthetic biology: Application in disease diagnosis. Pharma Innovation 2022;11(12):119-123.
Journal code(s)
- E-ISSN Number: 2277-7695
- P-ISSN Number: 2349-8242
- CODEN Code: PIHNBQ
- ZDB-Number: 2663038-2
- IC Journal ID: 7725
Main Menu
Special Issue
Copyright Form
Identifier
The Pharma Innovation Journal
