Vol. 10, Issue 8 (2021)

Author(s):
J Ramesh, B Anilkumar, B Kalakumar, P Shivakumar, M Jeevanalatha, Y Ravikumar and S Pavankalyan

Abstract:
The protective effect of pomegranate juice (fruit juice extract) were studied against anti-TB drugs (INH+RIF+PZA) induced haematological alterations. A total of twenty four male wistar albino rats of 3 months age were procured for the study. The rats were randomly divided into four groups, consisting of six in each group. Isoniazid @27mg/kg BW, Rifampicin @54mg/kg BW and Pyrazinamide @135mg/kg BW were administered daily orally to groups 2, 3, &4 from day 1 to 28. Group 1 was maintained as normal control. Group 2 was kept as toxic control (administered anti-TB drugs, p/o). Groups 3 and 4 were administered (p/o) with Enalapril @5mg/kg BW and Punica granatum (fresh juice extract) @1ml/rat, respectively from day 1 to 28. Body weights were measured, whole blood collection done on day 14th and 28th for estimation of haematology. The results of haematological parameters in the present study revealed that, the means of TEC, TLC, Hb and PCV were significantly (p<0.05) reduced in group 2 and increased significantly (p<0.05) in groups 3 & 4 at different time intervals. In conclusion, Punica granatum was found to possess haemoprotective action and it was comparable to enalapril. The beneficial effects of pomegranate juice extract could be attributed to antioxidant actions of the phytoconstituents.