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Vol. 10, Issue 7 (2021)

Study of ameliorative effect of quercetin on methotrexate induced toxicity on body weights and haematological parameters in albino Wistar rats

Author(s):
Kadudula Aparna, D Madhuri, M Lakshman, B Anilkumar, B Swathi and Y Ravikumar
Abstract:
The amelioration effect of quercetin on Methotrexate induced toxic effect on body weights and haematological parameters were studied in Wistar rats. The experiment was carried on 48 healthy albino Wistar rats (200-220 g) according to the guidelines and prior approval of Animal Ethics Committee. Animals were divided into four groups consisting of 12 in each group. Group1-Control, group 2-Methotrexate treated rats @ 8mg/kg b.wt (i.p) weekly once. Group 3-treated with Methotrexate @ 8mg/kg b.wt, (i.p) weekly once and quercetin @ 80mg/kg b.wt, Orally daily. Group 4-treated with quercetin @ 80mg/kg b.wt, orally daily. The experiment was carried out for a period of 28 days and rats were sacrificed on 14th and 28th day of experimental study. Significant (P< 0.05) reduction in b. wts were recorded in group 2 rats. All the Heamatological parameters were significantly reduced in group 2 and significant improvement of all parameters was noticed in ameliorative group (group 3).
Pages: 1434-1436  |  239 Views  60 Downloads


The Pharma Innovation Journal
How to cite this article:
Kadudula Aparna, D Madhuri, M Lakshman, B Anilkumar, B Swathi, Y Ravikumar. Study of ameliorative effect of quercetin on methotrexate induced toxicity on body weights and haematological parameters in albino Wistar rats. Pharma Innovation 2021;10(7):1434-1436.

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