Simple and rapid RP-HPLC determination of nimesulide in tablets
Author(s): Ravshankhon Makhmudov and Furkat Yunusov
Abstract: The present investigation describes a fast and simplified RP-HPLC method for the evaluation of nimesulide in tablets. The method is specific, accurate, precise, and ensures good reproducibility. The sample was analyzed using Acetonitrile (ACN): Ethanol: Water in the ratio of 40:40:20 as a mobile phase at a flow rate of 1.0 ml/min and detection at 276 nm. The retention time for nimesulide was found to be about 3.4, and a recovery from tablet was 99%. The method can be used for the fast and simple quantitative estimation of nimesulide in tablets.