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Vol. 10, Issue 1 (2021)

In vitro and in vivo safety evaluation of Thespesia populnea mediated nanoparticles

Author(s):
Jayasri A, P Eswara Prasad, K Padmaja, BDP Kala Kumar, M Gnanaprakash and M Sonali
Abstract:
The present study was conducted to evaluate the in vitro and in vivo safety of Thespesia populnea mediated nanoparticles. In the present study of MTT assay, the mouse spleenocytes maintained a survivability of 90% at concentrations of 500 μg/ml of TPE, 42.5μg/ml of TPNS and 100 μg/ml of TPNZ respectively indicating a safe margin to use the drug at higher concentrations. In the in vivo safety evaluation study, oral dose of 2000, 6.8 and 80 mg/kg of TPE, TPNS and TPNZ respectively was given to mice. The acute oral toxicity test and administration of the drugs at the limit dose did not result in any mortality nor any symptoms of toxicity. There were no changes either in body weights or in necropsy findings. Hence, this dose was considered as the stopping criteria as per the guidelines and the LD50 was assumed to be more than the upper bound dose administered for each test compound.
Pages: 09-11  |  872 Views  283 Downloads


The Pharma Innovation Journal
How to cite this article:
Jayasri A, P Eswara Prasad, K Padmaja, BDP Kala Kumar, M Gnanaprakash, M Sonali. In vitro and in vivo safety evaluation of Thespesia populnea mediated nanoparticles. Pharma Innovation 2021;10(1):09-11.

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