Design, development and in vitro evaluation of colon specific, pulsatile drug delivery system of lornoxicam
Balkrishna Gaikwad, Sourabh Jain and Karunakar Shukla
The intent of the present investigation is to develop colon targeted press coated Lornoxicam pulsatile release tablets that retard the drug release in the upper gastro intestinal system but progressively release in the colon. Lornoxicam core tablets were prepared by direct compression method and were compression coated with LM Amidated pectin, polycarbophil and guar gum. The formulation is optimized based on the in vitro drug release study and further evaluated for stability studies. The optimized formulations (CP5 and CP12) showed maximum lag period followed by progressive release (98.89±0.98 % and 99.08±1.15 % respectively for 15h). It was concluded that prepared colonspecific pulsatile release tablet of Lornoxicam was found to be satisfactory in terms of release of the drug after a predetermined lag time. Lag time of formulation can be modified by varying the ratio of LM Amidated Pectin to Polycarbophil and LM Amidated Pectin to Guar gum in coating blend. Development of pulsatile release compression coated tablets using combination of time dependent and pH sensitive approaches was suitable to target the Lornoxicam to colon.
How to cite this article:
Balkrishna Gaikwad, Sourabh Jain, Karunakar Shukla. Design, development and in vitro evaluation of colon specific, pulsatile drug delivery system of lornoxicam. Pharma Innovation 2020;9(9):12-20.