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Vol. 9, Issue 3 (2020)

Ameliorative effect of Andrographis paniculata against oxidative damage caused by cisplatin in rat kidney

Author(s):
T Rajendrakumar, Suguna Rao, ML Satyanarayana, HD Narayanaswam, SM Byregowda and KM Purushotham
Abstract:
The role of ethanolic extract of Andrographis paniculata [AP], in preventing cisplatin [CP] induced oxidative damage in rat kidney was studied. Sixty Wistar Albino rats were divided into five groups with twelve rats in each group. Group I served as normal control group. To group II rats, CP was administered at 7.5mg/kg body weight intraperitoneally for single dose. Rats in group III served as AP control and were administered AP at the dose of 500mg/kg body weight for 45 days. Group IV rats were pre-treated with AP fifteen days prior to CP administration and followed by AP treatment for 45 days. Rats in group V were administered with CP and concurrently treated with AP extract at 500mg/kg by oral gavaging for 45 days. The kidney samples collected at 7th, 14th, 28th, and 45th day of the study were subjected for estimation of catalase, superoxide dismutase, glutathione peroxidase and malondialdehyde [MDA]. Significant decrease [P<0.05] in the levels of antioxidant enzymes and increase in MDA levels were recorded in CP treatment group. The AP treatment groups revealed a significant recovery [P<0.05] all enzymes and decrease in MDA levels which suggested that AP has a good antioxidant effect and could be effectively used for prevention of toxic side effects of CP. The study also indicated that pre-treatment of AP prior to CP administration has good prophylactic effect.
Pages: 356-359  |  511 Views  120 Downloads


The Pharma Innovation Journal
How to cite this article:
T Rajendrakumar, Suguna Rao, ML Satyanarayana, HD Narayanaswam, SM Byregowda, KM Purushotham. Ameliorative effect of Andrographis paniculata against oxidative damage caused by cisplatin in rat kidney. Pharma Innovation 2020;9(3):356-359.

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