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Vol. 9, Issue 10 (2020)

Synthesis and biological evaluation of new hydrazone

Author(s):
Bushra Parveen and Arvind Kumar
Abstract:
Synthesis of new hydrazone derivatives, starting from 2-(3,4-Dichloro-benzoyl)-benzoic acid to 2-(3,4-Dichloro-benzoyl)-benzoic acid ethyl ester than converted into 2-(3,4-Dichloro-benzoyl)-benzoic acid hydrazide with substituted aromatic ketones. The structures of the newly synthesized compounds were confirmed by analytical and spectral analysis of IR, 1H NMR and MASS spectroscopy. The in-vitro antibacterial screening of synthesized compounds was performed against the following standard bacterial strains Escherichia coli (MTCC 1573), and staphylococcus aureus (MTCC 1430). Compound 2-(3,4-dichloro-bezoyl)-benzoic acid [1-(4-bromo-phenyle)-ethyledene]-hydrazide (BP-10), gives the highest activity on Escherichia coli (MTCC 1573) and staphylococcus aureus (MTCC 1430). The in-vitro anthelmintic activity was evaluated on Adult earthworms (Pheretima posthuma). Compound 2-(3,4-dichloro-bezoyl)-benzoic acid (2-oxo-1,2-diphynyl-ethylidene)-hydrazide (BP-7), and 2-(3,4-dichloro-bezoyl)-benzoic acid (2-oxo-1,4-chlorophenyle-ethylidene)-hydrazide (BP-13), gives the highest activity and other is gives the moderate activity against Adult earthworms (Pheretima posthuma).
Pages: 506-512  |  575 Views  241 Downloads


The Pharma Innovation Journal
How to cite this article:
Bushra Parveen, Arvind Kumar. Synthesis and biological evaluation of new hydrazone. Pharma Innovation 2020;9(10):506-512. DOI: 10.22271/tpi.2020.v9.i10g.5284

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