Vol. 8, Issue 6 (2019)

Author(s):
Arun Kumar, Narendra Singh Jadon and Rashmi Saini

Abstract:
The objective of the study was to evaluate a safe oncolytic drugs that could lead to fast and safe apoptic effect on canine transmissible venereal tumour (CTVT) and to determine various clinicophysiological and haematobiochemical parameters before and after treatment. Twelve dogs of either sex with canine transmissible venereal tumour (CTVT) used in the study were divided into two groups viz. A and B. The animals were administered with different drug viz. vincristine sulphate intravenously @ 0.025 mg/kg body weight, at weekly interval for four consecutive weeks and cisplatin @ 2.14 mg/kg intravenously once and repeat after 21 days in animals of group A and B respectively. The physical appearance in relation to onoclytic effect, histopathological changes, hematobiochemical parameters were studied at zero week, first, second, third and fourth week by using standard protocol. On the basis of parameter observed in this study, it was concluded that extent of apoptosis in CTVT cell at first and second week interval was more in the animals treated vincristine sulphate as compare to cisplatin as indicated by physical appearance and histopathological (H&E staining) examination. The early and best regression of the CTVT was observed in the animals treated with vincristine sulphate. Cisplatin regressed the CTVT masses upto some extent by apoptosis; Vincristine sulphate is effective drug for the treatment of CTVT even in metastatic conditions as compare to cisplatin.