Vol. 8, Issue 6 (2019)

Author(s):
M Rajyalakshmi, D Madhu Prasad and K Sunita

Abstract:
Malaria pathogenesis is associated with changes in lipid profile and kidney function. The present study was aimed to observe the changes in lipid profile and kidney function biomarkers in Plasmodium berghei infected mice treated with artemisinin-based combination drugs i.e., Artesunate + Amodiaquine (ASAQ), Artesunate + Sulfadoxine Pyrimethamine (ASSP) and Artesunate + Lumefantrine (AL). The Total cholesterol (TC), low-density lipoproteins (LDL), very low-density lipoproteins (VLDL) and triglycerides (TG) were increased whereas high-density lipoproteins (HDL) were decreased in P. berghei infected mice. Serum creatinine, urea and potassium ion levels were increased whereas sodium ions and chloride ions were decreased in P. berghei infected mice. When these infected mice were treated with ASAQ, ASSP and AL; all the above parameters were restored significantly (P <0.05) to normal values. Among these three drug combinations; ASAQ was the most effective than ASSP and AL in treating P. berghei infection in experimental mice.