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Vol. 8, Issue 11 (2019)

A computer aided approach to develop herbal acaricide using Leucas aspera and Cassia alata against the cattle tick Rhipicephalus (Boophilus) microplus

Author(s):
M Nithya Priyadarshini, SP Preetha, PL Sujatha, M Thangapandiyan, G Sarathchandra, P Sriram and C Yogesh
Abstract:
Rhipicephalus (Boophilus) microplus is one of the most important tick species affecting the cattle population. It can cause severe economic loss to cattle and dairy production worldwide and can be responsible for the transmission of many protozoan diseases. Chemical acaricides that are used to control ticks causes resistance development and also leads to deleterious effects on the environment in terms of residues. This served as the driving force to develop herbal acaricides using in silico studies. Leucas aspera and Cassia alata are common plants in India with proven medicinal properties. Docking studies using Discovery accelrys studio was carried out using the active principles present in the two plants on the two target proteins from R. (B). microplus namely Boophilin and Triosephosphate isomerase (TIM).The computational studies showed good interaction between the target proteins and active principles of the two plants. The Pharmacokinetic and pharmacodynamics prediction also showed the efficacy of the drug molecules without side effects. The study shows the positive synergistic role of both the plants as potential herbal acaricide. However, the results need to be validated using in vitro and in vivo studies.
Pages: 79-87  |  1005 Views  223 Downloads


The Pharma Innovation Journal
How to cite this article:
M Nithya Priyadarshini, SP Preetha, PL Sujatha, M Thangapandiyan, G Sarathchandra, P Sriram, C Yogesh. A computer aided approach to develop herbal acaricide using <em>Leucas aspera </em>and <em>Cassia alata </em>against the cattle tick <em>Rhipicephalus </em>(<em>Boophilus</em>) microplus. Pharma Innovation 2019;8(11):79-87.

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