Vol. 7, Issue 9 (2018)

Author(s):
TI Vlasiuk and OYa Zhurakivska

Abstract:
The purpose of this study is to shine a light on the structural changes of atrial cardiomyocytes of rats with streptozotocin-induced diabetes mellitus (DM) and the course of its treatment. DM was modeled by a single intraperitoneal administration of streptozotocin (dilutedin 0.1 М ofcitrate buffer with the pH of 4.5 at a dose of 6 mg per 100 grams ofbodymass). Antidiabetic therapy was performed with exenatide starting from the 14th day of the experiment. It is established that daily exenatide injections lead to a good glycemic control only at the initial stage of the experiment.However, its use as a monotherapy is not justified for correction of diabetes due to poor glycemic control and levels of glycosylated hemoglobin during later terms of the experiment. Using exenatide in experiment, we did not observe the repair of the structure of atrial cardiomyocytes in the late stages of experimental streptozotocin-induced DM.