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Vol. 7, Issue 8 (2018)

Formulation and in vitro evaluation of captopril floating tablets by using natural polymers

Author(s):
Ayesha Salma Habeeb and Shahidulla SM
Abstract:
The objective of this research is to formulate and develop gastroretentive floating matrix tablets of Captopril using natural polymers by effervescent system which will retain the drug upto 12 hours, to prepare and evaluate floating tablets of Captopril using natural polymers karaya gum, badam gum alone and in combination. Sodium bicarbonate is used as effervescent component, tablets were compressed using direct compression and wet granulation methods. The prepared tablets showed acceptable physico-chemical characteristics, floating characteristics (floating lag time, floating time), swelling index, drug content and evaluated for in vitro release characteristics for 12hours in 0.1N HCl. Drug compatibility with excipients was checked by FTIR studies. Formulations with low concentration of polymers were unable to produce the desired action. The formulations prepared with combination of polymers (Karya gum+ Badam Gum) was retarding the drug release up to 12 hours (F11=96.68). From the release kinetics data it was evident that the formulation followed Higuchi release mechanism.
Pages: 82-89  |  567 Views  42 Downloads
How to cite this article:
Ayesha Salma Habeeb, Shahidulla SM. Formulation and in vitro evaluation of captopril floating tablets by using natural polymers. Pharma Innovation 2018;7(8):82-89.
The Pharma Innovation Journal