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Vol. 7, Issue 4 (2018)

A novel solubility enhancement approach of poorly soluble drug: Ziprasidone by liquid compacts

Author(s):
Sravan Kumar Aligeti, Veerareddy Prabhakar Reddy and G Girija Sastri
Abstract:
Liquisolid system refers to the formulations that are formed by conversion of liquid drugs, drug suspensions or drug solution in non-volatile solvents into dry, non adherent, free flowing and compressible powder mixture by blending with suitable carrier and coating materials. Hence the dissolution step, a pre-requisite for drug absorption, is by passed and better bioavailability of poorly soluble drug is achieved. The purpose of this study is to develop novel a liquisolid technique to enhance the dissolution rate of poorly water soluble drug Ziprasidone. The main components of a liquisolid system are a non-volatile solvent, carrier and coating materials and a disintegrant. F5 of Ziprasidone was showing 99.6% release hence it was considered as optimized formula, F5 formulation having 50% drug concentration in Cremophore, with R value 25 and Lf value 0.312 was showing 99.6% release. Hence it can be appealed for further research of Ziprasidone.
Pages: 1095-1111  |  248 Views  113 Downloads


The Pharma Innovation Journal
How to cite this article:
Sravan Kumar Aligeti, Veerareddy Prabhakar Reddy, G Girija Sastri. A novel solubility enhancement approach of poorly soluble drug: Ziprasidone by liquid compacts. Pharma Innovation 2018;7(4):1095-1111.

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