Present study was evaluated the neuroprotective effect of hesperidin against ischemia-reperfusion induced cerebral infarction in rats.
Cerebral ischemia was induced by the transient occlusion of bilateral common carotid arteries for 30 min followed by 12 hrs reperfusion (I/C) in rats. Hesperidin (10 and 20 mg/kg orally) was treated for 14 consecutive days before ischemic reperfusion. After 12 hr reperfusion rats were killed, brains were removed and subjected to measurement of percentage of cerebral infract volume and malondialdehyde, superoxide dismutase, catalase and inflammatory markers (MPO, TNF-α, IL-10) markers in the brain tissue. The results of this study showed that hesperidin significantly reduced ischemic damage in hesperidin treated rats (20 mg/kg orally) when compared with I/C rats group, and also hesperidin treatment significantly reduced malondialdehyde levels, increased superoxide dismutase, catalase, decreased inflammatory mediators like MPO, TNF-α, IL-10 brain tissue in intact group when compared with I/C group.
Hesperidin alleviated neurological function in rats and the mechanism may be related to augmentation in endogenous antioxidant defense and inhibition of oxidative stress in the rat brain.