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Vol. 6, Issue 3 (2017)

Investigation of pharmacological activity the new antidiabetic plant gathering in streptozotocin-nicotinamide-induced diabetes in the rats

Author(s):
Alona Savych and Svitlana Marchyshyn
Abstract:
Diabetes mellitus is a global problem today, because there is a sharp increase the number of patients in the world each year. Severe complications of diabetes are very dangerous because it can lead to disability of patients and high mortality.
The purpose of the study was to establish the antidiabetic property of new plant gathering (consisting of Equiseti arvensis herba, Sambuci flores, Inulae rhizomata et radices, Hyperici herba, Tiliae flores, Polygoni avicularis herba, Myrtilli folium, Urticae folia) in Streptozotocin-Nicotinamide-induced diabetic type 2 in the rats.
Experimental diabetes type 2 was reproduced on rats by a single intravenous dose of Streptozotocin at 65 mg/kg. Solution of Streptozotocin was prepared in 0.1 M citrate buffer pH 4.5. To reduce the action of substance that causes diabetes was injected Nicotinamide at a dose of 230 mg/kg for 15 minutes before entering of Streptozotocin.
The results showed that the using of antidiabetic plant gathering for four weeks reduced the expressiveness of hyperglycemia, prevented the development of secondary insulin resistance and increased the tolerance to glucose in rats with Streptozotocin-Nicotinamide -induced diabetes, which showed the normalization coefficient of insulin sensitivity and approximation of glycemic reaction to carbohydrate load to the level of normal control.
The antidiabetic plant gathering was not inferior to reference drug Metformin and prevailed officinal plant gathering "Arphasetynum" for hypoglycemic action.
Pages: 175-177  |  905 Views  15 Downloads
How to cite this article:
Alona Savych, Svitlana Marchyshyn. Investigation of pharmacological activity the new antidiabetic plant gathering in streptozotocin-nicotinamide-induced diabetes in the rats. Pharma Innovation 2017;6(3):175-177.
The Pharma Innovation Journal