Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

NAAS Rating: 5.03, Impact Factor: RJIF 5.98 | Free Publication Certificate
updates
NAAS Rating: 5.03 new
Vol. 6, Issue 2 (2017)

Association of T-786C polymorphism of endothelial oxide synthase gene with rheumatoid arthritis

Author(s):
Larysa Sydorchuk, Olga Bukach, Olexandr Fediv, Andriy Sydorchuk, Marianna Semianiv, Yulia Repchuk, Ruslan Sydorchuk, Yulia Yarynych, Oksana Korovenkova and Lubov Kriklyvetz
Abstract:
The aim of the study was to analyze the frequency of alleles/genotypes of eNOS gene T-786C polymorphism in patients with rheumatoid arthritis (RA), Arterial Hypertension (AH), Obesity (AO), type 2 Diabetes Mellitus (DM2), and their association with severity and RA clinical manifestation. The eNOS T-786C gene polymorphism was analyzed by polymerase chain reaction in 60 patients with RA and 20 healthy individuals. Wild T-allele dominates over mutant C-allele in the population by 30% (р<0.001). Frequency of comorbid pathology (AO, DM2 and AH) in patients with RA didn't depend on analyzed gene polymorphic variants. Among Т-allele carriers there were more patients with a painful joints number >10 by 37.94% (р=0.004) and 73.92% (р<0.001); among the ТС-variant carriers there were more subjects with swelling joints number >10 by 47.82% (р=0.001); all CC-genotype patients complained of heart pain; morning stiffness with duration of ≥6 hours didn't depend on analyzed gene polymorphism.
Pages: 116-120  |  961 Views  16 Downloads
How to cite this article:
Larysa Sydorchuk, Olga Bukach, Olexandr Fediv, Andriy Sydorchuk, Marianna Semianiv, Yulia Repchuk, Ruslan Sydorchuk, Yulia Yarynych, Oksana Korovenkova, Lubov Kriklyvetz. Association of T-786C polymorphism of endothelial oxide synthase gene with rheumatoid arthritis. Pharma Innovation 2017;6(2):116-120.
The Pharma Innovation Journal