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Vol. 5, Issue 8 (2016)

Pharmaceutical applications of hot melt extrusion technology: An overview

Deepak Kaushik
Hot-melt extrusion (HME) has emerged as a promising technique to develop several types of pharmaceutical dosage forms and drug delivery systems. The absence of solvents, fast processing, simple and continuous operation, high degree of automation, and ability to process poorly compactable material into tablet form are some of the advantages offered over conventional processing by this innovative technique. The basic steps involved in this technique are mixing and melting an active pharmaceutical ingredient (API), polymer, and other excipients in a melt extruder and then forcing it through dies with one or more rotating screws to obtain the desired product. The materials used in hot melt extruded products must possess some degree of thermal stability in addition to acceptable physical and chemical stability. Interest in HME as a pharmaceutical process continues to grow and recent success of this technique have made it worthy of consideration as a drug delivery solution.
Pages: 22-26  |  1475 Views  39 Downloads
How to cite this article:
Deepak Kaushik. Pharmaceutical applications of hot melt extrusion technology: An overview. Pharma Innovation 2016;5(8):22-26.
The Pharma Innovation Journal