Effective pain management remains a challenge for healthcare professionals. Much research has been directed in the recent years for want of an effective, potent analgesic that can be used chronically with least adverse effects. Levetiracetam has shown analgesic properties and exerts synergy in combination with non-steroidal anti-inflammatory drugs. To this purpose of the study is to compare the combined effect of Levetiracetam and Aspirin against the standard drug aspirin in inflammation-induced thermal hyperalgesia model in rats.
Methods: Male Wistar rats weighing 200-250gms aged 3-4 months were randomized to 4 groups containing six animals each: group-I(control)- distilled water, group-II (standard) -Tab. Aspirin 100 mg/kg, group-III (Test)-Tab. Levetiracetam 100 mg/kg and Group-IV (combined) – Tab. Aspirin 50mg/kg + Tab. Levetiracetam 50 mg/kg. Test compounds are administered orally1hour after injecting carrageenan into the sub plantar region of left hind paw. The analgesic activity of a drug is its ability to increase the mean reaction time and percentage increase in reaction time.
Results: The analgesic effect of Levetiracetam (100 mg/kg) is less that of Aspirin (100 mg/kg). The combined effect of Levetiracetam (50 mg/kg) and Aspirin (50 mg/kg) is comparable to the standard drug Aspirin (100 mg/kg).
Conclusion: The results of our study indicate that Levetiracetam (100 mg/kg) has an analgesic effect but less than that of the standard drug Aspirin (100 mg/kg).Half dose of Levetiracetam plus half dose of Aspirinisas effective as aspirin full dose in increasing reaction times to thermal stimulus. Due to this synergistic action, the dose- dependent adverse effects of aspirin-like gastrointestinal bleeding can be avoided when given in combination.