Abstract:Background: Type 2 diabetes mellitus (T2DM) is associated with various cardiovascular complications, including left ventricular diastolic dysfunction (LVDD). This study aims to explore the association between glycemic control and the presence of LVDD in newly detected Type 2 Diabetes Mellitus, highlighting the potential role of glycemic parameters in the early detection of cardiovascular dysfunction.
Materials and Methods: This prospective study was conducted at the Department of General Medicine, Shri Shankar Acharya Institute of Medical Sciences, Bhilai, from March 2015 to February 2016, involving 125 newly diagnosed T2DM patients. The study included patients without cardiovascular symptoms or major comorbidities. Participants underwent clinical examinations, laboratory tests, and Doppler echocardiography to assess left ventricular diastolic function, with parameters such as HbA1c, fasting and postprandial blood sugars (FBS and PPBS) being evaluated.
Results: The study found that the majority of LVDD-positive patients were in the 41-50 years age group, with a higher percentage of males affected. Significant differences were observed in glycemic control, with 59.57% of LVDD-positive patients having HbA1c levels greater than 10%. Higher fasting and postprandial blood sugar levels were also strongly associated with LVDD. The majority of patients with LVDD had Grade I LVDD (89.36%).
Conclusion: The study concluded that poor glycemic control, particularly elevated HbA1c and higher fasting and postprandial blood sugar levels, is significantly associated with the presence of LVDD in newly diagnosed T2DM patients. These findings emphasize the need for early glycemic control to prevent cardiovascular complications in diabetic patients.