The Role of Tissue Inhibitor of Matrix Metalloproteinase-1 in Cardiac and Blood Vessels Remodeling and in Potential for Survival in Case of Chronic Heart Failure of Various Origins
RI Yatsyshyn and TI Salyzhyn
Results. Direct moderate reliable connection was established between TIMP-1 and end-diastolic volume (EDV) (r=+0.36; p<0.05), left ventricular mass index (LVMI) (r=+0.46; p<0.05), thickness of left ventricular posterior wall (r=+0.33; p<0.05), interventricular septum thickness (r=+0.39; p<0.05) in Group I (p<0.05), whereas the connection between TIMP-1 and end-systolic volume (ESV) (r=+0.36; p<0.05), EDV (r=+0.38; p<0.05), LVMI (r=+0.42; p<0.05), anteroposterior dimension of right ventricle (r=+0.43; p<0.05) was established in Group II. In order to assess the impact of TIMP-1 on ED we conducted correlation analysis between TIMP-1 and ET-1 between the studied parameters in both groups, in Group I (r=+0.73; р<0.001) and in Group II (r=+0.70; р<0.001). Increase in TIMP-1 level over 1040 ng/ml was associated with a greater risk of hospitalization for CHF decompensation and cardiovascular complications (CVC) development during 2 years in patients of both groups. Conclusions. The results of this research indicate that increased TIMP-1 level is an independent predictor of increase in hospitalization and mortality of patients with CHF regardless of renal function. Increase in TIMP-1 level may promote cardiac and blood vessels remodeling in patients with comorbidities. Increase in TIMP-1 level is associated with the development of endothelial dysfunction in both groups.
How to cite this article:
RI Yatsyshyn, TI Salyzhyn. The Role of Tissue Inhibitor of Matrix Metalloproteinase-1 in Cardiac and Blood Vessels Remodeling and in Potential for Survival in Case of Chronic Heart Failure of Various Origins. Pharma Innovation 2016;5(10):85-91.