Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

Free Publication Certificate

Vol. 4, Issue 8 (2015)

Effects of added intrathecal clonidine on spinal anaesthesia with bupivacaine 0.5 percent: A comparative controlled clinical study

Author(s):
Dr. PB Jamale and Dr. Mrs SV Nike
Abstract:
Aim: To evaluate the efficacy and adverse effects of small dose clonidine 75μg added to 0.5% hyperbaric bupivacaine administered intrathecally in patients undergoing elective.
Material and method: In the premedication room pulse rate, BP, Respiratory rate and SpO2 were noted. An IV line was secured. Preloading done with Ringer lactate (15-20 ml/kg) over 20-30 mints. In the Operation theatre appropriate equipment for airway management and emergency drugs were kept ready. Patient was shifted from the premedication room to Operation theatre. The horizontal position of the operating table was checked and the patient was placed on it. Noninvasive blood pressure, SpO2, ECG leads were connected to the patient. Preoperative base line systolic and diastolic BP, PR, SpO2 and RR were recorded.
Result: The mean weight for group BC (study) was 51.14±4.82 and for group B (control) was 50.68±4.61. By using 2 independent sample t-tests, p-value was 0.627. Since the p-value is > 0.05 therefore there is no significant difference between weights (kg) in group “BC” and “B”. Sex wise comparison of demographic parameters in group “BC” (study) and group “B” (control).We have done our study for lower abdominal surgeries. The patients included in the present study were only female patients in both the groups i.e. group BC and group B.
Conclusion: The addition of 75μg of Clonidine to 2ml of 0.5% hyperbaric Bupivacaine provide late onset of sensory and motor block, excellent surgical anaesthesia with relative hemodynamic stability, good sedation, prolonged post-operative analgesia and reduces the postoperative analgesic requirements. Clonidine provides maximum benefit and minimum side effects.
Pages: 147-150  |  556 Views  95 Downloads


The Pharma Innovation Journal
How to cite this article:
Dr. PB Jamale, Dr. Mrs SV Nike. Effects of added intrathecal clonidine on spinal anaesthesia with bupivacaine 0.5 percent: A comparative controlled clinical study. Pharma Innovation 2015;4(8):147-150.

Call for book chapter