Vol. 4, Issue 6 (2015)

Author(s):
Shisir Kumar Sharma Poudel, Bhupendra Kumar Poudel, Junu Khatri Silwal

Abstract:
Aceclofenac, a non steroidal anti-inflammatory drug (NSAID), inhibits the enzyme cyclooxygenase which is responsible for the production of prostaglandins. It is the glycolic acid ester of diclofenac. The present work is based in designing effervescent tablets of aceclofenac. The aceclofenac effervescent tablets were prepared by wet granulation method. The alterations in the effervescence time of the prepared tablets were studied by varying the concentrations of acid and base materials, i.e. citic acid, sodium bicarbonate and tartaric acid. On the basis of the effervescence time, an optimum formulation was chosen. The results revealed that the formulated batch which consists of 20% w/w, 50.85% w/w and 25.58%w/w of citric acid, sodium bicarbonate and tartaric acid respectively was chosen as an optimum formulation with effervescence time of 276.5 seconds.And as we increase or decrease the amount of citric acid and sodium bicarbonate from the amount used for the optimum formulation, the effervescent time tend to increase as observed in formulations. So the concentrations of the citric acid and sodium bicarbonate must be as that of F8 (optimum formulation) to get the better effervescent time. Therefore, aceclofenac effervescent tablets can be prepared by wet granulation method.