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Vol. 3, Issue 6 (2014)

Marine sponge and its potential bioactive spectrum against CSF affected bacterial organisms

Author(s):
S. Sujatha, G. Prakash Vincent and M. Jobi Dhas
Abstract:
Sponges are sessile filter feeders that have developed efficient defense mechanisms against foreign invaders such as viruses, bacteria or eukaryotic organisms. Antimicrobial activities are known as principal functional important immune defense system in marine invertebrates. The aim of the present work was to study the antimicrobial properties of the eight Indian sponges against the CSF affected pathogenic bacterial organisms viz., E. coli S. aureus H. influenzaeN. meningitides Klebsiella pneumoniaeStreptococcus agalactiae,Pseudomonas fluorescensEnterococcus faecalis. From the present result clealrly expressed the maximum peak activity was noted on two experimental sponges such as Ircinia fusca andSigmadocia carnosa crude extract showed that the peak activity 21±3.64 and 20±3.15 bioactivity against the pathogens of H. influenzae and N. meningitides respectively. Consequently another maximum zone of inhibition (17±2.32) formed with the sponge-5 extract on K. pneumoniae. The present result denoted on both sponge extract antimicrobial activity at 5% level of statistically significant. Although, least antimicrobial response was observed in Cacospongia salaries on K. pneumoniae (3.41±0.21) also D. nigra extract againstS. agalactiae (2.30±0.41). From the over all results depicted statistically insignifiant response also noted on ms-2,3 against E.coli 5±2.58 and H. influenzae 7±2.10. The present study depicted that the chromatogram stands for compounds elucidation by GCMS on the methanol extract experimental sponge of Ircinia fusca. Initially nine compounds were categorized. Among the nine compounds, two antimicrobial compounds are present such as 2-Methoxy-1, 4-Benzenediol recognized as a peak compound subsequently 3-dimethylocta-1, 5-dien-3, 7-diol- dimethyltryptamine also been elucidated. The response of this kind of secondary metabolic compounds was act as potential antimicrobial compound against the experimental CSF pathogen derived from the tested marine sponges. Hence, this research focused a new source of marine sponge as a poised potential antimicrobial agent for the control the CNS involved pathogenic microbiota.
Secondary screening of antibacterial activity of eight Marine sponges against the various CSF influenced Bacterial Pathogens
Fig.: Secondary screening of antibacterial activity of eight Marine sponges against the various CSF influenced Bacterial Pathogens
Pages: 81-86  |  901 Views  13 Downloads
How to cite this article:
S. Sujatha, G. Prakash Vincent, M. Jobi Dhas. Marine sponge and its potential bioactive spectrum against CSF affected bacterial organisms. Pharma Innovation 2014;3(6):81-86.
The Pharma Innovation Journal