Vol. 2, Issue 2 (2013)

Author(s):
Vaibhav Gadade*, Ashok Gadade, Dhanvantari Shivarkar, Tushar Katariya

Abstract:
Current research in the field of drug delivery devices, pulsatile drug delivery systems (PDDS) are gaining importance, as these systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved patient therapeutic efficacy and compliance. Diseases wherein pulsatile drug delivery systems are promising include asthma, peptic ulcer, cardiovascular diseases, arthritis, attention deficit syndrome in children, and hypercholesterolemia. These systems are beneficial for the drugs having chronopharmacological behavior where night time dosing is required and for the drug having high first pass metabolism effect and having specific site of absorption in gastrointestinal tract. In pursuit of pulsatile release, various design strategies have been proposed, mainly including time controlling, stimuli induced and externally regulated formulations. In this article, an attempt has been made to discuss several types of drug delivery systems developed by various researchers that show pulsatile drug delivery characteristics.