Volume5, Issue3
Solid as solvent: Novel spectrophotometric analytical technique for quantitative analysis of tinidazole tablets using solids (eutectic liquid of phenol and metformin hydrochloride) as solubilizing agents (mixed solvency concept)
Author: RK Maheshwari, Akash P Shah, Lovkush Pandey, Shivam Prasad Tiwari
Abstract:
The main objective of the present study is to demonstrate the solvent action of solid. In the present study, a eutectic liquid (PMHCl 41) obtained by triturating phenol crystals and metformin hydrochloride in 4:1 ratio on weight basis was employed to extract (dissolve) tinidazole drug from fine powder of its tablets. Distilled water was used for dilution to carry out spectrophotometric estimation at 318 nm without the help of organic solvent. The solubility of tinidazole in distilled water at room temperature was found to be 5.38 mg/ml. The solubility of the same drug in PMHCl 41 was more than 150 mg per ml (of PMHCl 41). Proposed spectrophotometric analytical method is novel, rapid, free from toxicity of organic solvent, accurate and reproducible. Recovery studies and statistical data proved the accuracy, reproducibility and precision of the proposed method. The presence of tablet excipients, phenol and metformin hydrochloride did not interfere in the spectrophotometric estimation at 318 nm. Phenol and metformin hydrochloride do not interfere above 300 nm.
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