Volume5, Issue2
Morphology of fetal liver under the influence of silver and gold citrates on a background of lead intoxication in rats
Author: Vira Harets, Vira Shatorna, Iuliia Belska, Tatiana Demchenko
Abstract:
Background: Pregnant women and children are especially sensitive to lead exposure. Natural trace elements with bio antagonistic properties against lead are known. However, liver organogenesis under combined influence of silver and gold citrates on a background of lead intoxication isn’t studied enough.
Methods: the aim of present study was to identify morphological state of fetal liver under combined influence of silver, gold and lead acetate.
Results: combined influence of silver citrate and lead acetate caused increase of fetal liver weight and number of hepatocytes, while the relative area of blood vessels and number of hematopoietic cells were reduced.
Conclusions: morphological state of fetal liver was improved by injection of silver citrate on a background of lead intoxication; oxidative stress was decreased; processes of maturation and differentiation of liver cells were improved.
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