Volume5, Issue1
Effect of L-arginine on blood pressure profile and bronchial patency in patients with hypertension burdened by pulmonary hypertension of bronchopulmonary origin
Author: Luybov Dron, Iryna Kupnovytska
Abstract:The article deals with the problem of peripheral hemodynamics correction in the systemic and pulmonary circulation, circadian profiles of blood pressure and respiratory ventilation in patients with stage 2 hypertension, burdened by obstructive pulmonary disease, with the use of L-arginine – exogenous source of nitric oxide.
Material and methods of investigation: This study investigated 100 patients with stage 2 hypertension (2nd- and 3rd-degree) including 80 patients with hypertension, burdened by stage 2 pulmonary hypertension of bronchopulmonary origin, and 20 patients with essential hypertension of the identical stage and degree at the age of 56.5±4.12.
Results: It has been observed that chronic obstructive disease burdens the course of hypertension by peripheral hemodynamics deterioration and systolic pressure increase in the pulmonary circulation leading to heart remodeling. A number of positive effects of L-arginine on the course of the cardiovascular and respiratory systems comorbide pathology have been established.
Conclusions: L-arginine, used in combination therapy in patients with hypertension accompanied by chronic obstructive disease, induces antihypertensive therapy potentiation, bronchial patency improvement, and circadian profiles of blood pressure resetting.
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