Volume5, Issue1
Pathogenetic grounds for the development of insulin resistance in patients suffering from primary hypothyroidism
Author: OM Didushko
Abstract: The main objective of the research was to study the levels of leptin, adiponectin, interleukin-6 (IL-6) and indices of insulin resistance in patients with primary hypothyroidism. The article reveals literary and personal data showing the role of leptin and adiponectin in the development of insulin resistance associated with obesity in patients with primary hypothyroidism. 112 patients, including 62 women and 50 men, suffering from primary hypothyroidism were examined. A positive correlative linear connection between HOMA IR and TSH levels has been established. Reasonably high levels of leptin and low levels of adiponectin have been detected in all patients under study with manifested hypothyroidism in comparison to control group. A positive correlation between IL-6 and leptin levels has been found, but the relation between IL-6 and adiponectin has proved to be negative, which confirms our suggestion that leptin, adiponectin and IL-6 participate in the development of insulin resistance in patients with primary hypothyroidism. Hyperleptinemia and hypoadiponectinemia may be considered the markers of hypothyroidism with elements of metabolic syndrome.
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