Volume 4, Issue 9
Impact of myocardial revascularization, irregular administration of bisoprolol, perindopril and antithrombotic drugs on heart remodeling and development of complications in acute myocardial infarction during 29.5 months
Denesiuk OV
Abstract: 21 male patients with AMI with ST segment elevation treated in Vinnytsia town clinical hospital № 1 in infarction unit from 2009 to 2014 years were examined. AMI with comorbid arterial hypertension was observed in 19 (90.5%) patients. HF of I-III functional classes was determined in all examined patients. To control the performed treatment lipid blood spectrum, troponin 1 content ECG, EchoCG in M and V regimes, Coronarography were used. Examined patients irregularly used BAB bisoprolol in the dose of 5-10 mg/24h, ACEI perindopril- 5-10 mg/24h and antithrombotic preparations (acetylsalicylic acid and clopidogrel) during in average 29.5 months. In patients with AMI with ST segment elevation eccentric LHV and different degrees of LHV and dilation of left ventricle were determined before the treatment. After prolonged treatment accidental regress of heart remodeling and development of cardiac events (cardiac death - in 1 patient, nonfatal MI- in 2, stroke - in 2, repeated revascularization- in 1, fibrillation of ventricles- in 2 patients) occurred, that gives the evidence of ineffectiveness of performed therapy.
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