Volume 4, Issue 9
Optimization of formulation parameters for controlled drug delivery from Metformin Hydrochloride loaded Chitosan/TPP microspheres
KS Singh, M Vasundhara
Abstract: Diabetes contributes to a major health burden on humans and India has emerged as Diabetes capital of the world. Due to extensive research and demand for novel therapeutics, many agents have been formulated to mitigate disease and improve patient health, one of which is Metformin. This drug has good performance but controlled drug release formulations are required to improve patient compliance and drug bioavailability. We aimed to formulate controlled drug release system using Chitosan/TPP mixture and study their behavior in buffered gastrointestinal conditions. Different parameters such as percentage of Chitosan, TPP, drug and varied stirring time were used to prepare different batches. These batches were checked for best controlled drug release characteristics in buffered gastrointestinal conditions. High level of sustained drug release was observed in a batch which also has good morphology, drug encapsulation and equilibrium swelling characteristics. As all the trials have been conducted at room temperature, we present a tunable controlled drug release system, showing Metformin as a model drug, for which there is high industrial scalability.
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