Volume 4, Issue 8
Technology development of herbal remedies for androgenic alopecia external application
MI Fedorovska, IO Yarema
Abstract: This work is aimed to substantiate the method of Saw Palmetto extract introduction to emulsion bases in technology development of medicines for androgenic alopecia treatment using physical-chemical and biopharmaceutical analysis. At the first stage it was investigated the solubility of Saw Palmetto extract in different liquids: pumpkin seed oil, water, glycerin, propylene glycol, alcohol-water-glycerol mixture (1:6:3), ethanol 48%. The results showed that it is impossible to achieve complete dissolution of the substance with any liquid, but microscopic analysis showed that the 48 % ethanol provide the dispersion of the extract with particles size 0.005-0.05 mm. The next step was in vitro agar plates biopharmaceutical study of the Saw Palmetto extract penetration from emulsion bases, which was inserted by mixing with 48 % ethanol, glycerin, alcohol-water-glycerol mixture (at the end of technology) and pumpkin seed oil (at the beginning of emulation bases preparation). Thus it was found that the optimum method of extract introduction to emulsion bases is adding it at the end of the technological process in the form of a finely dispersed suspension with 48% ethanol.
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