Volume 4, Issue 5
Formulation and Evaluation of Chewable Tablets of Loratadine by Wet Granulation Method
Author: Pawan Jalwal, Jyoti Dahiya, Balvinder Singh, Renu
Abstract: Chewable tablets are made especially for pediatric and geriatric patients. It improves the therapeutic efficacy and better bioavailability. Loratadine is a second-generation H1 histamine antagonist drug used to treat allergies. Loratadine is used for the symptomatic relief of allergy such as hay fever (allergic rhinitis), urticaria and seasonal allergies, including sneezing, itchy and runny nose, and tearing and redness of the eyes. It is a peripherally selective piperidine histamine receptor blocker, which competitively antagonizes histamine at the H1 receptor site. It stimulates the cells to release chemicals that produce effects associated with allergy and commonly acts on α-adrenergic receptor or 5-HT receptor.
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