Volume 4, Issue 5
Influence of acute prenatal hypoxia on secretory activity of rat atrial cardiomyocytes during the stages of ontogenesis
Author: K. M. Shevchenko, I. M. Shevchenko
Abstract: We have performed a quantitative ultrastructural analysis of secretory apparatus of rat atrial cardiomyocytes during the stages of ontogenesis after the influence of acute intrauterine hypoxia. Analysis showed that on the 16th day of embryogenesis (3rd day after influence of acute hypoxia) numerical density and relative volume of the secretory granules of rat atrial cardiomyocytes were lower than control group. Experimental group animals had granules of type III in the cytoplasm. Thus, acute hypoxia stimulates the release of atrial natriuretic peptide. However, these changes were transient and were tending to the values the control group on the 18th day of embryogenesis (5th day after the influence of acute hypoxia).
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