Volume 4, Issue 5
A comparative study of thrombolytic effects of methanolic extract of Bridelia stipularis and Aglaonema hookerianum leaf
Author: Md. Shahrear Biozid, Mohammad Nazmul Alam, Md. Ferdous Alam, Md. Ashraful Islam, Md. Hasibur Rahman
Abstract: Objective: To evaluate thrombolytic activities of crude methanol extract of B. stipularis and A. hookerianum Leaf. Methods: The thrombolytic activity was evaluated using the in vitro clot lysis model. In a brief, venous blood drawn from five healthy volunteers was allowed to form clots which were weighed and treated with the test plant materials to disrupt the clots. Weight of clot after and before treatment provided a percentage of clot lysis and compared the result with streptokinase as positive control and water as negative control. Results: In thrombolytic study, it is found that B. stipularis and A. hookerianum showed 33.42 ± 3.37% and 24.72 ± 2.75% of clot lysis respectively. Among the herbs studied B. stipularis, showed very significant (p < 0.001) percentage (%) of clot lysis than the A. hookerianum compared to reference drug streptokinase (63.54 ± 2.61%). Conclusion: The results of the study demonstrated that the leaf of the plants contains promising thrombolytic activity in vitro when tested on human blood. However, further study is needed to see its potentiality as a thrombolytic agent.
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