Volume 4, Issue 4
The potential of nano technology based drugs in lung cancer management
Author: Tolosa Ketema Bayisa, Mohammed Hussen Bule, Jimma Likisa Lenjisa
Abstract: Nanotechnology is defined as research and technology development at the atomic, molecular, or macromolecular level, in the length scale of approximately 1-100 nanometer (nm) range, to provide a fundamental understanding of phenomena and materials at the nanoscale and to create and use structures, devices, and systems that have novel properties and functions because of their small and/or intermediate size. Active and passive delivery is among the two type of nanoparticle based drug delivery system. Although, nanoparticle based drug delivery show some limitation, their advantage increase their need worldwide. This special property assigned to them attracts many scholars to apply it for controlling many chronic diseases like asthma, HIV, lung cancer and etc.
Lung cancer is the leading cause of mortality and morbidity among cancer related death worldwide. Among this 85%-90% of lung cancer death is contributed by non-small cell lung cancer. This extreme mortality rate is arises due to lack of suitable pharmaceutical care and ineffective convectional therapeutic strategies. In course with desperate attempts to address these issues independently nanomedicine based therapeutics is being sought as favorable solution. Despite the fact that physiochemical property of nanoparticles increases the need for nanomedicine, the aspect of being at nano scale by itself confers the system with an advantage of passive accumulation at the site of tumor. However there is work left behind the scientists to widely apply these smart new technologies to increase patient out come and minimize healthy cost. Generally, a broad perspective of three major subclasses of such nanoscale based lung cancer drug delivery approach namely; polymeric nanoparticles approach, metal based nanoparticles and bio-nano particle approach are widely applicable.
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