Volume 4, Issue 4
Influence of Anti-anginal therapy on essential amino acids in the blood plasma content of the blood of patients with stable angina
Author: Zavalska TV
Abstract: The study includes 55 patients with SA on exertion (functional class II – III) between the ages of 59 to 75 years (mean age of patients was 68, 2 ± 4,2 years). As the object of studies is serum amino acids. So the method of ion-exchange liquid-column chromatography is used. In the blood plasma were determined the following essential amino acids arginine, valine, histidine, isoleucine, leucine, lysine, methionine, tryptophan, fenilalanin. The study was carried out before and after the treatment (after 15-17 days). All patients received conventional antianginal therapy (beta-blocker (Bisoprolol - 5 mg), antiplatelet agents (Acetylsalicylic acid - 75 mg), a statin (Atorvastatin 10 mg), an ACE inhibitor (Enalapril 10 mg). Under the influence of antianginal therapy, it showed a significant decrease in the following essential amino acids: arginine, valine, histidine, isoleucine, leucine, lysine, threonine in the blood serum. Such amino acid changes of blood serum after treatment may indicate that, under the action of antianginal therapy, the metabolism of essential amino acids is enhanced and the synthesis of bioactive substances, improves antiplatelet blood system, the Krebs cycle, the immune system, the exchange of higher fatty acids.
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