Volume 4, Issue 4
Ameliorating potentials of aqueous extract of Talinum triangulare (Waterleave) against acetaminophen–induced hepatotoxicity in Wistar albino rats
Author: Afolabi OB, Obafemi TO, Awe JO, Jaiyesimi KF, Anadozie SO, Olayide II, Afolabi BA
Abstract: The antagonistic potentials of aqueous extract of Talinum triangulare (Tt) against Acetaminophen-induced damage in the hepatic cells were concisely studied in randomly grouped female Wistar albino rats. The dosage of the extract received by the various groups was based on the average weight of each group. Negative control group received normal animal feed and water ad libitum, the Control group (Positive) received 200 mg/ml Acetaminophen without Tt while group 1 received 200 mg/ml Acetaminophen with 100 mg/kg Tt. On the other hand, based on average weight, group 2 received 200 mg/kg Tt with 200 mg/ml Acetaminophen and group 3 received 200 mg/ml Acetaminophen alongside with the counter dose of 300 mg/kg of the extract. The levels of liver marker enzymes, malondialdehyde (MDA) and reduced glutathione (GSH) in the tissue of the animals (both the treated and untreated) were estimated after the experiment. The result showed a significant (p < 0.05) increase in the level of ALT, ALP and AST in both the liver and serum. Also, a significant (p < 0.05) decrease was observed in the GSH level in the serum of the tested groups when compared to the control group (positive). Severe liver impairment was observed in the Control group (Negative) based on histophotographic analysis and ameliorating effects were observed in the Tt treated groups significantly.
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