Volume 4, Issue 4
Evaluation of anti bacterial activity of Coccinia grandis leafs and stem extracts
Author: Kavitha A, Krishna Reddy B, Niharika J, Venkata Rao Vutla, Narendra Babu A
Abstract: The Coccinia grandis is having anti bacterial activity and every part of this plant is valuable in medicine and various preparations in indigenous system of medicine for various skin disease, bronchitis, psoriasis, smallpox, ulcers and it is having the antilithic, hypolipidemic, antimutagenic and hypoglycemic activities. In this study the in vitro antibacterial activity of leafs and stem extracts were tested against gram positive and gram negative organisms bacterial strains by agar well disc plate method. The crude extract showed a broad spectrum of antibacterial activity by inhibiting both the gram positive and gram negative groups. The antibacterial activity of C. grandis leaf extract using solvents such as ethanol, ethyl acetate was evaluated against The gram positive strains such as St. aureus, B. substillus and in gram negative strains such as E. coli (ETEC), P.a. Minimal inhibitory concentration of the leaf extract against each test organism was also studied by observing their growth on Mueller Hinton Agar containing the extract at various incremental levels, equivalent to 50 µg/ml to 500 µg/ml of the extract. The highest activity was observed in ethanol stem extract against both against gram positive and gram negative organism’s bacterial strains with an inhibitory concentration below 50 µg/ml. The significance of the study was conducted to investigate the in vitro antibacterial activity of Coccinia grandis plant and to evaluate scientific base of their applications.
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