Volume 4, Issue 3
Synthesis, characterisation and in vitro Evaluation of some novel 1h-1, 2, 4-Triazole-3-Thiol derivatives
Author: Kandula Priyanka, K. Sudha Rani, T. Sarala Devi, KNV Chenchu Lakshmi
Abstract: Conventional synthesis of 1H-1,2,4-triazole-3-thiol derivatives have been synthesized at laboratory scale by condensation of 5-oxazolones prepared from various aldehydes with thiosemicarbazide. The compounds structures were characterized by IR, H1 NMR and C13 NMR. All the compounds have been evaluated for antimicrobial and antioxidant activity by in vitro methods and were compared with their corresponding standards. Of all the synthesised derivatives compounds 3a, 5a, 7a, 12a exhibited good antimicrobial properties.
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