Volume 4, Issue 3
Review of Preliposomes as novel drug delivery system
Author: Hiral Manani, Bijal Prajapati, Rakesh Patel
Abstract: Liposomes colloidal drug delivery system is broadly applicable for the novel drug delivery systems. Provesicular drug delivery system like preliposomes having distinct advantages over conventional drug delivery system. Conventional liposomes having the problem associated with instability to overcome that problem preliposomes were discovered by Payne et al. in 1986. Preliposomes are dry powder, having free-flowing granular products composed of phospholipid and drug which, upon hydration with water, disperse and form a multi lamellar liposomal suspension. Preliposomes composed of water soluble porous powder as carrier which having ability to rapid hydration of preliposomes and formed vesicles. New concept of demonstrating preliposomes as novel carrier to enhance the oral bioavailability and permeation across the membrane. On basis of investigation it is clear that preliposomes are the alternate drug carrier for the various route of administration. These reviews give the brief knowledge about the preparation, evaluation and application of provesicular drug delivery system in pharmaceutical field.
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