Volume 4, Issue 2
Formulation and development of sustained release metformin hydrochloride tablet
Author: Puratchikody A, Shanmugarathinam A, Hari PG, Faritha Begam N, Sridhar G
Abstract: The objective of the work was to develop Metformin Hydrochloride sustained release tablet using Hypromellose (HPMC) as polymer by wet granulation method. Hypromellose 15 cps and 1 lakh cps were used by varying their proportion to develop sustained release tablets. All the batches were evaluated for thickness, weight variation, thickness, hardness, friability, percentage of drug content and in vitro release profiles. Formulation F5 was found to release drug at the regular interval up to 10 hr.
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