Volume 4, Issue10
Synthesis, characterization and pharmacological evaluation of cinnoline (thiophene) derivatives
Author: Mishra Pankaj, Saxena Vikas, Kesheri Minu, Saxena Abhishek
Abstract: The review of literature showed that cinnoline derivatives were found to elicit many pharmacological actions like anti-hypertensive, antithrombotic, antihistamine, antileukemic, CNS activity, anti tumor, antibacterial and antisecretory activity.
In the substituted Cinnoline thiophene series, the compounds which are halogen mainly Chloro, Bromo and Fluoro Substituted were showed potent antibacterial, anti-inflammatory and anti-fungal activity than other compounds. Especially Chloro Substituted Compounds Showed more potent antimicrobial activity and anti-inflammatory activity among all the substituted cinnoline thiophene compounds.
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