Volume 3, Issue 5
Spectrophotometric Method Development and Validation for Montelukast Sodium and Simvastatin in Bulk and Tablet Dosage Form Using Absorption Ratio Method
Author: D. Sathis Kumar, Lps. Nainesha Allada, Y. Narayudu
Abstract: A simple, economic, and accurate absorption ratio method was developed for the simultaneous estimation of Montelukast Sodium (MTK) and Simvastatin (SMV) in bulk and tablet dosage form. 0.1M NaOH was used as a diluent to dissolve MTK and SMV. The absorptions were observed at 244 nm (Isosbestic point) and 295 nm (λmax of MTK) which were selected based on overlapping spectra of SMV and MTK. The linearity range was found to be 2-10 µg/ml at 244 nm (r2= 0.998±0.001) and 295 nm (r2= 0.998±0.0008). The method was found to be simple, precise, accurate and rapid for the simultaneous determination of SMV and MTK in bulk and tablet dosage form using absorption ratio method. Recovery study was performed to confirm the accuracy of the methods. The methods were validated as per ICH guidelines.
Fig: Structures of drugs Montelukast and simvastatin (images are derived from http://en.wikipedia.org)
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