Volume 3, Issue 12
Preparation, in vitro and in vivo characterization of solid dispersions of Oxcarbazepine using melting technique
Author: Arti Mohan, M.Madhavi, P.Jyosthna
Abstract: Oxcarbazepine is one of the newer antiepileptic drugs and low aqueous solubility of Oxcarbazepine is responsible for its poor dissolution and delayed onset of action. The purpose of the present investigation is to increase the dissolution rate of Oxcarbazepine by preparing its solid dispersions with PEG 6000 using melting technique and subjecting the prepared solid dispersions to drug-carrier interaction, dissolution and stability studies and it was found that the dissolution rate was improved for Oxcarbazepine in its solid dispersion. As indicated from XRD and DSC studies, Oxcarbazepine was in the amorphous form in the solid dispersions, which confirmed the better dissolution rate of prepared stable solid dispersions. Pharmacokinetic profiles of Oxcarbazepine and solid dispersion were compared by one way ANOVA followed by a Dunnett Post Hoc test which indicated higher attainable plasma concentrations. Solid dispersion showed a difference with the pure drug in its pharmacokinetic profile which may be attributed to better dissolution rate of Oxcarbazepine from its solid dispersion.
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