Volume 3, Issue 11
Development of an Anti-obesity Polyherbal Formulation containing Terminalia arjuna, Lagenaria siceraria and Piper nigrum.
Author: Pallavi D. Rai, Amol A. Dambal, Smriti Khatri, S.S. Khadabadi
Abstract: Obesity is one of the most common health problems and has become an epidemic on the global scale. In the present study, new anti-obesity polyherbal formulations were developed and their effect was studied in female rats fed on high fat diet. Obesity was induced in wistar albino rats by feeding them with high fat diet for 28 days. Group-I served as normal control (1% Carboxy Methyl Cellulose (CMC)) and Group-II as obese control (1% CMC) fed on high fat diet, Group- III, IV, V, VI were treated with various polyherbal tablet formulations of Lagenaria siceraria alone or in combination with other plant extracts of Terminalia arjuna and Piper nigrum (400 mg/kg body wt) and Group-VII served as marketed formulation (400 mg/kg body wt), Group-VIII served as positive standard (Orlistat 45 mg/kg body wt). All the animals except normal control were fed on high fat diet. The animals were treated for 14 days. On 14th day, 2 hrs after drug administration, the body weight, organ weights, locomotor activity and various biochemical parameters like Total Cholesterol (TC), Triglycerides (TG), High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL) levels were determined. There was a significant reduction in food intake, body weight, organ weights, TC, TG, LDL, locomotor activity and an increase in HDL levels in high fat diet fed rats treated formulation containing Lagenaria siceraria, Terminalia arjuna and Piper longum as compared to the Positive Standard, Marketed and Normal treated animals.
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