Volume 3, Issue 10
Reviewing biomedical role of Plasma Gelsolin.
Author: Neeraj Khatri, Ashish and Veena Garg
Abstract: Gelsolin is circulating in human plasma in extremely high concentrations that is exhausted by intermediaries of inflammation and largely produced by skeletal muscles. Gelsolin is a Ca2+ dependant actin-binding and an actin-depolymerizing protein. Owing to capability of gelsolin to swiftly severe F-actin, plasma gelsolin has become a very important injury healing protein in various pathological conditions. Decreased levels of the plasma gelsolin have been reported in human diseases as well as in animal models of diseases. Therefore, pGSN deficiency appears to be a powerful biomarker and a potential therapeutic target in diseases. Here, we review the biomedical functions of gelsolin and impact of gelsolin levels in different disease conditions.
Download Full Article: Click Here
Support Us
If you are interested in supporting our work and would like to contribute, you are welcome to mail me at jpbr.anil@gmail.com or at info@thepharmajournal.com it will be a great help and will surely be appreciated.
