Volume 3, Issue 1
Synthesis of 5-R-4-R1-3-alkylthio-1,2,4-triazoles and study influence of their adsorption ability on the results of toxicity and anti-hypoxic activity
Author: Yu. M. Kucheryavyi 1, A. G. Kaplaushenko 2, A. S. Korzhova 3
1. Department of Physical and Colloidal Chemistry, Zaporozhye State Medical University, Zaporozhye, Ukraine
E-mail: kucherjavy@zsmu.zp.ua; Tel: +380661925705]
2. Department of Physical and Colloidal Chemistry, Zaporozhye State Medical University, Zaporozhye, Ukraine.
[E-mail: kaplaushenko@ukr.net; Tel: +380953506704]
3. Department of Physical and Colloidal Chemistry, Zaporozhye State Medical University, Zaporozhye, Ukraine
Abstract: During our research of biologically active substances we have synthesized series of new 5-R-4-R1-3-alkylthio-1,2,4-triazoles for original drugs creation. 14 new compounds have been synthesized in total. The structure of it has been confirmed by a complex of modern physical and chemical methods of analysis. For these compounds the data of toxicity, anti-hypoxic activity, surface activity and adsorption ability has been set. The obtained results of biological activity have been compared with data of adsorption properties of 1,2,4-triazoles derivatives to establish structure-action regularity.
The dependence of adsorption from the concentration of compounds 9, 12, 14,18
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